AustralieFrV1, Main, Exploration, bibRecord, 000411

SC83288 is a clinical development candidate for the treatment of severe malaria

Identifieur interne : 000411 ( Main/Exploration ); précédent : 000410; suivant : 000412

SC83288 is a clinical development candidate for the treatment of severe malaria

Auteurs : Stefano Pegoraro [Allemagne] ; Maëlle Duffey [Allemagne] ; Thomas D. Otto [Royaume-Uni] ; Yulin Wang [Allemagne] ; Roman Rösemann [Allemagne] ; Roland Baumgartner [Allemagne] ; Stefanie K. Fehler [Allemagne] ; Leonardo Lucantoni [Australie] ; Vicky M. Avery [Australie] ; Alicia Moreno-Sabater [France] ; Dominique Mazier [France] ; Henri J. Vial [France] ; Stefan Strobl [Allemagne] ; Cecilia P. Sanchez [Allemagne] ; Michael Lanzer [Allemagne]

Source :

Nature Communications [ 2041-1723 ] ; 2017.

RBID : PMC:5290327

Abstract

Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe a medicinal chemistry program starting from amicarbalide that led to two compounds with optimized pharmacological and antiparasitic properties. SC81458 and the clinical development candidate, SC83288, are fast-acting compounds that can cure a P. falciparum infection in a humanized NOD/SCID mouse model system. Detailed preclinical pharmacokinetic and toxicological studies reveal no observable drawbacks. Ultra-deep sequencing of resistant parasites identifies the sarco/endoplasmic reticulum Ca²⁺ transporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288. Features, such as fast parasite killing, good safety margin, a potentially novel mode of action and a distinct chemotype support the clinical development of SC83288, as an intravenous application for the treatment of severe malaria.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290327

DOI: 10.1038/ncomms14193
PubMed: 28139658
PubMed Central: 5290327

Affiliations:

Allemagne, Australie, France, Royaume-Uni

Le document en format XML

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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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, F-75013 Paris,<country>France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Vial, Henri J" sort="Vial, Henri J" uniqKey="Vial H" first="Henri J" last="Vial">Henri J. Vial</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Strobl, Stefan" sort="Strobl, Stefan" uniqKey="Strobl S" first="Stefan" last="Strobl">Stefan Strobl</name>
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<author><name sortKey="Sanchez, Cecilia P" sort="Sanchez, Cecilia P" uniqKey="Sanchez C" first="Cecilia P" last="Sanchez">Cecilia P. Sanchez</name>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>German Center for Infection Research (DZIF), partner site Heidelberg</institution>
, 69120 Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lanzer, Michael" sort="Lanzer, Michael" uniqKey="Lanzer M" first="Michael" last="Lanzer">Michael Lanzer</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Infectious Diseases, Parasitology, Universitätsklinikum Heidelberg</institution>
, Im Neuenheimer Feld 324, 69120 Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>German Center for Infection Research (DZIF), partner site Heidelberg</institution>
, 69120 Heidelberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Severe malaria is a life-threatening complication of an infection with the protozoan parasite <italic>Plasmodium falciparum</italic>
, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe a medicinal chemistry program starting from amicarbalide that led to two compounds with optimized pharmacological and antiparasitic properties. SC81458 and the clinical development candidate, SC83288, are fast-acting compounds that can cure a <italic>P. falciparum</italic>
 infection in a humanized NOD/SCID mouse model system. Detailed preclinical pharmacokinetic and toxicological studies reveal no observable drawbacks. Ultra-deep sequencing of resistant parasites identifies the sarco/endoplasmic reticulum Ca<sup>2+</sup>
 transporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288. Features, such as fast parasite killing, good safety margin, a potentially novel mode of action and a distinct chemotype support the clinical development of SC83288, as an intravenous application for the treatment of severe malaria.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dondorp, A M" uniqKey="Dondorp A">A. M. Dondorp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ashley, E A" uniqKey="Ashley E">E. A. Ashley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jimenez Diaz, M B" uniqKey="Jimenez Diaz M">M. B. Jimenez-Diaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Charman, S A" uniqKey="Charman S">S. A. Charman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vial, H J" uniqKey="Vial H">H. J. Vial</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Held, J" uniqKey="Held J">J. Held</name>
</author>
<author><name sortKey="Jeyaraj, S" uniqKey="Jeyaraj S">S. Jeyaraj</name>
</author>
<author><name sortKey="Kreidenweiss, A" uniqKey="Kreidenweiss A">A. Kreidenweiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cosledan, F" uniqKey="Cosledan F">F. Cosledan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hameed, P S" uniqKey="Hameed P">P. S. Hameed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramachandran, S" uniqKey="Ramachandran S">S. Ramachandran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nilsen, A" uniqKey="Nilsen A">A. Nilsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baragana, B" uniqKey="Baragana B">B. Baragana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaidya, A B" uniqKey="Vaidya A">A. B. Vaidya</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rolling, T" uniqKey="Rolling T">T. Rolling</name>
</author>
<author><name sortKey="Agbenyega, T" uniqKey="Agbenyega T">T. Agbenyega</name>
</author>
<author><name sortKey="Krishna, S" uniqKey="Krishna S">S. Krishna</name>
</author>
<author><name sortKey="Kremsner, P G" uniqKey="Kremsner P">P. G. Kremsner</name>
</author>
<author><name sortKey="Cramer, J P" uniqKey="Cramer J">J. P. Cramer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rehman, K" uniqKey="Rehman K">K. Rehman</name>
</author>
<author><name sortKey="Lotsch, F" uniqKey="Lotsch F">F. Lotsch</name>
</author>
<author><name sortKey="Kremsner, P G" uniqKey="Kremsner P">P. G. Kremsner</name>
</author>
<author><name sortKey="Ramharter, M" uniqKey="Ramharter M">M. Ramharter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Achan, J" uniqKey="Achan J">J. Achan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leban, J" uniqKey="Leban J">J. Leban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ashley, J N" uniqKey="Ashley J">J. N. Ashley</name>
</author>
<author><name sortKey="Berg, S S" uniqKey="Berg S">S. S. Berg</name>
</author>
<author><name sortKey="Lucas, J M" uniqKey="Lucas J">J. M. Lucas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Vos, A J" uniqKey="De Vos A">A. J. De Vos</name>
</author>
<author><name sortKey="Barrowman, P R" uniqKey="Barrowman P">P. R. Barrowman</name>
</author>
<author><name sortKey="Coetzer, J A" uniqKey="Coetzer J">J. A. Coetzer</name>
</author>
<author><name sortKey="Kellerman, T S" uniqKey="Kellerman T">T. S. Kellerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beveridge, G G L" uniqKey="Beveridge G">G. G. L. Beveridge</name>
</author>
<author><name sortKey="Thwaite, J W" uniqKey="Thwaite J">J. W. Thwaite</name>
</author>
<author><name sortKey="Shepherd, G" uniqKey="Shepherd G">G. Shepherd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reeh, C" uniqKey="Reeh C">C. Reeh</name>
</author>
<author><name sortKey="Wundt, J" uniqKey="Wundt J">J. Wundt</name>
</author>
<author><name sortKey="Clement, B" uniqKey="Clement B">B. Clement</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tilley, J W" uniqKey="Tilley J">J. W. Tilley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desjardins, R E" uniqKey="Desjardins R">R. E. Desjardins</name>
</author>
<author><name sortKey="Canfield, C J" uniqKey="Canfield C">C. J. Canfield</name>
</author>
<author><name sortKey="Haynes, J D" uniqKey="Haynes J">J. D. Haynes</name>
</author>
<author><name sortKey="Chulay, J D" uniqKey="Chulay J">J. D. Chulay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sanz, L M" uniqKey="Sanz L">L. M. Sanz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stead, A M" uniqKey="Stead A">A. M. Stead</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baumeister, S" uniqKey="Baumeister S">S. Baumeister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Angulo Barturen, I" uniqKey="Angulo Barturen I">I. Angulo-Barturen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ring, B J" uniqKey="Ring B">B. J. Ring</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name>
</author>
<author><name sortKey="Jusko, W J" uniqKey="Jusko W">W. J. Jusko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linder, P" uniqKey="Linder P">P. Linder</name>
</author>
<author><name sortKey="Jankowsky, E" uniqKey="Jankowsky E">E. Jankowsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rubio, J P" uniqKey="Rubio J">J. P. Rubio</name>
</author>
<author><name sortKey="Cowman, A F" uniqKey="Cowman A">A. F. Cowman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zalis, M G" uniqKey="Zalis M">M. G. Zalis</name>
</author>
<author><name sortKey="Wilson, C M" uniqKey="Wilson C">C. M. Wilson</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Wirth, D F" uniqKey="Wirth D">D. F. Wirth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenberg, E" uniqKey="Rosenberg E">E. Rosenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Velden, M" uniqKey="Van Der Velden M">M. van der Velden</name>
</author>
<author><name sortKey="Rijpma, S R" uniqKey="Rijpma S">S. R. Rijpma</name>
</author>
<author><name sortKey="Russel, F G" uniqKey="Russel F">F. G. Russel</name>
</author>
<author><name sortKey="Sauerwein, R W" uniqKey="Sauerwein R">R. W. Sauerwein</name>
</author>
<author><name sortKey="Koenderink, J B" uniqKey="Koenderink J">J. B. Koenderink</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="David Bosne, S" uniqKey="David Bosne S">S. David-Bosne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burrows, J N" uniqKey="Burrows J">J. N. Burrows</name>
</author>
<author><name sortKey="Van Huijsduijnen, R H" uniqKey="Van Huijsduijnen R">R. H. van Huijsduijnen</name>
</author>
<author><name sortKey="Mohrle, J J" uniqKey="Mohrle J">J. J. Mohrle</name>
</author>
<author><name sortKey="Oeuvray, C" uniqKey="Oeuvray C">C. Oeuvray</name>
</author>
<author><name sortKey="Wells, T N" uniqKey="Wells T">T. N. Wells</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uhlemann, A C" uniqKey="Uhlemann A">A. C. Uhlemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eckstein Ludwig, U" uniqKey="Eckstein Ludwig U">U. Eckstein-Ludwig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="David Bosne, S" uniqKey="David Bosne S">S. David-Bosne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mbengue, A" uniqKey="Mbengue A">A. Mbengue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steimer, L" uniqKey="Steimer L">L. Steimer</name>
</author>
<author><name sortKey="Klostermeier, D" uniqKey="Klostermeier D">D. Klostermeier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trager, W" uniqKey="Trager W">W. Trager</name>
</author>
<author><name sortKey="Jensen, J B" uniqKey="Jensen J">J. B. Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smilkstein, M" uniqKey="Smilkstein M">M. Smilkstein</name>
</author>
<author><name sortKey="Sriwilaijaroen, N" uniqKey="Sriwilaijaroen N">N. Sriwilaijaroen</name>
</author>
<author><name sortKey="Kelly, J X" uniqKey="Kelly J">J. X. Kelly</name>
</author>
<author><name sortKey="Wilairat, P" uniqKey="Wilairat P">P. Wilairat</name>
</author>
<author><name sortKey="Riscoe, M" uniqKey="Riscoe M">M. Riscoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elabbadi, N" uniqKey="Elabbadi N">N. Elabbadi</name>
</author>
<author><name sortKey="Ancelin, M L" uniqKey="Ancelin M">M. L. Ancelin</name>
</author>
<author><name sortKey="Vial, H J" uniqKey="Vial H">H. J. Vial</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ibrahim, N" uniqKey="Ibrahim N">N. Ibrahim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Rooijen, N" uniqKey="Van Rooijen N">N. Van Rooijen</name>
</author>
<author><name sortKey="Sanders, A" uniqKey="Sanders A">A. Sanders</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tacchini Cottier, F" uniqKey="Tacchini Cottier F">F. Tacchini-Cottier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quail, M A" uniqKey="Quail M">M. A. Quail</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otto, T D" uniqKey="Otto T">T. D. Otto</name>
</author>
<author><name sortKey="Sanders, M" uniqKey="Sanders M">M. Sanders</name>
</author>
<author><name sortKey="Berriman, M" uniqKey="Berriman M">M. Berriman</name>
</author>
<author><name sortKey="Newbold, C" uniqKey="Newbold C">C. Newbold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otto, T D" uniqKey="Otto T">T. D. Otto</name>
</author>
<author><name sortKey="Dillon, G P" uniqKey="Dillon G">G. P. Dillon</name>
</author>
<author><name sortKey="Degrave, W S" uniqKey="Degrave W">W. S. Degrave</name>
</author>
<author><name sortKey="Berriman, M" uniqKey="Berriman M">M. Berriman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Langmead, B" uniqKey="Langmead B">B. Langmead</name>
</author>
<author><name sortKey="Salzberg, S L" uniqKey="Salzberg S">S. L. Salzberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckenna, A" uniqKey="Mckenna A">A. McKenna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carver, T" uniqKey="Carver T">T. Carver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rohrbach, P" uniqKey="Rohrbach P">P. Rohrbach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lucantoni, L" uniqKey="Lucantoni L">L. Lucantoni</name>
</author>
<author><name sortKey="Duffy, S" uniqKey="Duffy S">S. Duffy</name>
</author>
<author><name sortKey="Adjalley, S H" uniqKey="Adjalley S">S. H. Adjalley</name>
</author>
<author><name sortKey="Fidock, D A" uniqKey="Fidock D">D. A. Fidock</name>
</author>
<author><name sortKey="Avery, V M" uniqKey="Avery V">V. M. Avery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lucantoni, L" uniqKey="Lucantoni L">L. Lucantoni</name>
</author>
<author><name sortKey="Fidock, D A" uniqKey="Fidock D">D. A. Fidock</name>
</author>
<author><name sortKey="Avery, V M" uniqKey="Avery V">V. M. Avery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, S" uniqKey="Duffy S">S. Duffy</name>
</author>
<author><name sortKey="Loganathan, S" uniqKey="Loganathan S">S. Loganathan</name>
</author>
<author><name sortKey="Holleran, J P" uniqKey="Holleran J">J. P. Holleran</name>
</author>
<author><name sortKey="Avery, V M" uniqKey="Avery V">V. M. Avery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turpeinen, M" uniqKey="Turpeinen M">M. Turpeinen</name>
</author>
<author><name sortKey="Uusitalo, J" uniqKey="Uusitalo J">J. Uusitalo</name>
</author>
<author><name sortKey="Jalonen, J" uniqKey="Jalonen J">J. Jalonen</name>
</author>
<author><name sortKey="Pelkonen, O" uniqKey="Pelkonen O">O. Pelkonen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karaman, M W" uniqKey="Karaman M">M. W. Karaman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boxenbaum, H" uniqKey="Boxenbaum H">H. Boxenbaum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gabrielsson, J" uniqKey="Gabrielsson J">J. Gabrielsson</name>
</author>
<author><name sortKey="Weiner, D" uniqKey="Weiner D">D. Weiner</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Pegoraro, Stefano" sort="Pegoraro, Stefano" uniqKey="Pegoraro S" first="Stefano" last="Pegoraro">Stefano Pegoraro</name>
</noRegion>
<name sortKey="Baumgartner, Roland" sort="Baumgartner, Roland" uniqKey="Baumgartner R" first="Roland" last="Baumgartner">Roland Baumgartner</name>
<name sortKey="Duffey, Maelle" sort="Duffey, Maelle" uniqKey="Duffey M" first="Maëlle" last="Duffey">Maëlle Duffey</name>
<name sortKey="Duffey, Maelle" sort="Duffey, Maelle" uniqKey="Duffey M" first="Maëlle" last="Duffey">Maëlle Duffey</name>
<name sortKey="Fehler, Stefanie K" sort="Fehler, Stefanie K" uniqKey="Fehler S" first="Stefanie K" last="Fehler">Stefanie K. Fehler</name>
<name sortKey="Fehler, Stefanie K" sort="Fehler, Stefanie K" uniqKey="Fehler S" first="Stefanie K" last="Fehler">Stefanie K. Fehler</name>
<name sortKey="Fehler, Stefanie K" sort="Fehler, Stefanie K" uniqKey="Fehler S" first="Stefanie K" last="Fehler">Stefanie K. Fehler</name>
<name sortKey="Lanzer, Michael" sort="Lanzer, Michael" uniqKey="Lanzer M" first="Michael" last="Lanzer">Michael Lanzer</name>
<name sortKey="Lanzer, Michael" sort="Lanzer, Michael" uniqKey="Lanzer M" first="Michael" last="Lanzer">Michael Lanzer</name>
<name sortKey="Rosemann, Roman" sort="Rosemann, Roman" uniqKey="Rosemann R" first="Roman" last="Rösemann">Roman Rösemann</name>
<name sortKey="Sanchez, Cecilia P" sort="Sanchez, Cecilia P" uniqKey="Sanchez C" first="Cecilia P" last="Sanchez">Cecilia P. Sanchez</name>
<name sortKey="Sanchez, Cecilia P" sort="Sanchez, Cecilia P" uniqKey="Sanchez C" first="Cecilia P" last="Sanchez">Cecilia P. Sanchez</name>
<name sortKey="Strobl, Stefan" sort="Strobl, Stefan" uniqKey="Strobl S" first="Stefan" last="Strobl">Stefan Strobl</name>
<name sortKey="Wang, Yulin" sort="Wang, Yulin" uniqKey="Wang Y" first="Yulin" last="Wang">Yulin Wang</name>
<name sortKey="Wang, Yulin" sort="Wang, Yulin" uniqKey="Wang Y" first="Yulin" last="Wang">Yulin Wang</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Otto, Thomas D" sort="Otto, Thomas D" uniqKey="Otto T" first="Thomas D" last="Otto">Thomas D. Otto</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Lucantoni, Leonardo" sort="Lucantoni, Leonardo" uniqKey="Lucantoni L" first="Leonardo" last="Lucantoni">Leonardo Lucantoni</name>
</noRegion>
<name sortKey="Avery, Vicky M" sort="Avery, Vicky M" uniqKey="Avery V" first="Vicky M" last="Avery">Vicky M. Avery</name>
</country>
<country name="France"><noRegion><name sortKey="Moreno Sabater, Alicia" sort="Moreno Sabater, Alicia" uniqKey="Moreno Sabater A" first="Alicia" last="Moreno-Sabater">Alicia Moreno-Sabater</name>
</noRegion>
<name sortKey="Mazier, Dominique" sort="Mazier, Dominique" uniqKey="Mazier D" first="Dominique" last="Mazier">Dominique Mazier</name>
<name sortKey="Mazier, Dominique" sort="Mazier, Dominique" uniqKey="Mazier D" first="Dominique" last="Mazier">Dominique Mazier</name>
<name sortKey="Moreno Sabater, Alicia" sort="Moreno Sabater, Alicia" uniqKey="Moreno Sabater A" first="Alicia" last="Moreno-Sabater">Alicia Moreno-Sabater</name>
<name sortKey="Vial, Henri J" sort="Vial, Henri J" uniqKey="Vial H" first="Henri J" last="Vial">Henri J. Vial</name>
</country>
</tree>
</affiliations>
</record>

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   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5290327
   |texte=   SC83288 is a clinical development candidate for the treatment of severe malaria
}}

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Serveur d'exploration sur les relations entre la France et l'Australie

SC83288 is a clinical development candidate for the treatment of severe malaria

SC83288 is a clinical development candidate for the treatment of severe malaria

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	Serveur d'exploration sur les relations entre la France et l'Australie
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